Dambatta, Mubarak B;
Santos, Joseph;
Bolt, Robert RA;
Morrill, Louis C;
(2020)
Transition metal free α-C-alkylation of ketones using secondary alcohols.
Tetrahedron
, 76
(45)
, Article 131571. 10.1016/j.tet.2020.131571.
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Abstract
A base-mediated α-C-alkylation of ketones with secondary alcohols has been developed. This transition metal free approach employs KOt-Bu as the base and exhibits a broad scope, allowing a range of commodity aliphatic secondary alcohols and 1-arylethanols to be employed as alkylating agents. Aryl methyl ketones undergo selective mono-α-C-alkylation in high isolated yields (23 examples, 65% average yield).
| Type: | Article |
|---|---|
| Title: | Transition metal free α-C-alkylation of ketones using secondary alcohols |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.tet.2020.131571 |
| Publisher version: | https://doi.org/10.1016/j.tet.2020.131571 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | C-alklation; Alcohols; Transition metal free |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10181507 |
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