Ray, César;
García-Sampedro, Andrés;
Schad, Christopher;
Avellanal-Zaballa, Edurne;
Moreno, Florencio;
Ortiz, María J;
Bañuelos, Jorge;
... De la Moya, Santiago; + view all
(2021)
Alkynyl N-BODIPYs as Reactive Intermediates for the Development of Dyes for Biophotonics.
Chemistry Proceedings
, 3
(1)
, Article 15. 10.3390/ecsoc-24-08374.
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Abstract
A new approach for the rapid multi-functionalization of BODIPY dyes towards biophotonics is reported. It is based on novel N-BODIPYs, through reactive intermediates with alkynyl groups to be further derivatized by click chemistry. This approach has been exemplified by the development of new dyes for cell bio-imaging, which have proven to successfully internalize into pancreatic cancer cells and accumulate in the mitochondria. The in vitro suitability for photodynamic therapy (PDT) was also analyzed and confirmed our compounds to be promising PDT candidates for the treatment of pancreatic cancer.
| Type: | Article |
|---|---|
| Title: | Alkynyl N-BODIPYs as Reactive Intermediates for the Development of Dyes for Biophotonics |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/ecsoc-24-08374 |
| Publisher version: | https://doi.org/10.3390/ecsoc-24-08374 |
| Language: | English |
| Additional information: | Copyright © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/4.0/). |
| Keywords: | N-BODIPYs; biophotonics; BODIPY functionalization; PDT; pancreatic cancer |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10181297 |
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