Haider, Lukas; Chung, Karen K; Mangesius, Stephanie; Furtner, Julia; Ciccarelli, Olga; Chard, Declan T; Barkhof, Frederik; (2023) The relation of sarcopenia and disability in multiple sclerosis. Multiple Sclerosis and Related Disorders , 77 , Article 104855. 10.1016/j.msard.2023.104855.

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Abstract

Background: The relation of sarcopenia and disability in MS is unknown. Objective: To investigate the relation of temporal muscle thickness (TMT) and disability. Methods: A cohort of 132 people who presented with a clinically isolated syndrome (CIS) suggestive of MS at a mean age of 30.0 years, were prospectively followed clinically and with MRI over 30-years. TMT and expanded disability status scale (EDSS) were assessed at baseline, one- five- ten- fourteen- twenty- and thirty-year follow-up. Results: At 30-years, 27 participants remained classified as having had a CIS, 34 converted to relapsing remitting MS, 26 to secondary progressive MS, and 16 had died due to MS. Using linear mixed effect models with subject nested in time, greater annualized TMT-thinning was seen in individuals who developed MS (-0.04 mm/a, 95%CI: -0.07 to -0.01, p = 0.023). In those who converted to MS, a thinner TMT was reached at 14- (p = 0.008), 20- (p = 0.002) and 30-years (p< 0.001). TMT was negatively correlated with EDSS at 20-years (R=-0.18, p = 0.032) and 30-years (R-0.244, p = 0.005). Longitudinally, TMT at earlier timepoints was not predictive for 30-year clinical outcomes. Conclusion: TMT thinning is accelerated in MS and correlated with disability in later disease stages, but is not predictive of future disability.

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