Louie, Karly S;
Dalel, Jama;
Reuter, Caroline;
Bissett, Sara L;
Kleeman, Michelle;
Ashdown-Barr, Lesley;
Banwait, Rawinder;
... Beddows, Simon; + view all
(2018)
Evaluation of Dried Blood Spots and Oral Fluids as Alternatives to Serum for Human Papillomavirus Antibody Surveillance.
mSphere
, 3
(3)
, Article e00043-18. 10.1128/msphere.00043-18.
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Abstract
Human papillomavirus (HPV) is the causative agent of cervical and other anogenital cancers. HPV vaccination, primarily targeted at young girls before the age of sexual debut, is starting to demonstrate population-level declines in HPV infection and early disease associated with vaccine-incorporated genotypes. Monitoring young women for vaccine-specific antibody is important for vaccine surveillance and may be useful as an adjunct test within a cervical screening context. We evaluated serum, dried blood spots, and oral fluid as potential samples for such applications and report robust measures of diagnostic accuracy. This is the first time a direct comparison of alternative sample types has been made between vaccinated and unvaccinated women for the detection and quantitation of HPV antibodies.
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