Nixon-Hill, Miranda;
Mookerjee, Rajeshwar P;
Leung, Terence S;
(2023)
Assessment of bilirubin levels in patients with cirrhosis via forehead, sclera and lower eyelid smartphone images.
PLOS Digital Health
, 2
(10)
, Article e0000357. 10.1371/journal.pdig.0000357.
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Abstract
One of the key biomarkers evaluating liver disease progression is an elevated bilirubin level. Here we apply smartphone imaging to non-invasive assessment of bilirubin in patients with cirrhosis. Image data was processed using two different approaches to remove variation introduced by ambient conditions and different imaging devices—a per-image calibration using a color chart in each image, and a two-step process using pairs of flash/ no-flash images to account for ambient light in combination with a one-time calibration. For the first time, results from the forehead, sclera (white of the eye) and lower eyelid were compared. The correlation coefficients between the total serum bilirubin and the predicted bilirubin via the forehead, sclera and lower eyelid were 0.79, 0.89 and 0.86 (all with p<0.001, n = 66), respectively. Given the simpler image capture for the sclera, the recommended imaging site for this patient cohort is the sclera.
| Type: | Article |
|---|---|
| Title: | Assessment of bilirubin levels in patients with cirrhosis via forehead, sclera and lower eyelid smartphone images |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pdig.0000357 |
| Publisher version: | https://doi.org/10.1371/journal.pdig.0000357 |
| Language: | English |
| Additional information: | © 2023 Nixon-Hill et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10178602 |
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