Jain, Dipty;
Kirkham, Fenella J;
(2023)
Laboratory Associations With Transcranial Doppler Categories in Sickle Cell Disease.
Indian Pediatrics
, 60
(8)
pp. 622-623.
10.1007/s13312-023-2957-3.
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Abstract
This issue of Indian Pediatrics carries an article by Mahmoud, et al. [1] that provides insight into the pathophysiology of cerebrovascular pathology in children with homozygous sickle cell disease (SCD), compound heterozygotes with hemoglobin Sβthalassemia, and controls. They found that platelet-derived growth factor (PDGF-AA) and homocysteine levels were higher in patients with SCD than controls, which is in agreement with previous data [2]. High homocysteine levels have long been recognized as a risk factor for vascular disease, and the thermolabile variant of the methylene tetrahydrofolate reductase gene is associated with ischemic stroke in adults with SCD [3], and predicts recurrence in children with stroke [4]. PDGF-AA is associated with vascular remodeling in response to challenges including infection e.g., cytomegalovirus [5,6], and increased shear stress related to high flow.
| Type: | Article |
|---|---|
| Title: | Laboratory Associations With Transcranial Doppler Categories in Sickle Cell Disease |
| Location: | India |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s13312-023-2957-3 |
| Publisher version: | https://doi.org/10.1007/s13312-023-2957-3 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10177547 |
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