Azimbagirad, Mehran;
Grillo, Felipe Wilker;
Hadadian, Yaser;
Carneiro, Antonio Adilton Oliveira;
Murta, Luiz Otavio;
(2021)
Biomimetic phantom with anatomical accuracy for evaluating brain volumetric measurements with magnetic resonance imaging.
Journal of medical imaging
, 8
(1)
, Article 013503. 10.1117/1.jmi.8.1.013503.
Preview |
Text
013503_1.pdf - Accepted Version Download (1MB) | Preview |
Abstract
Purpose: Brain image volumetric measurements (BVM) methods have been used to quantify brain tissue volumes using magnetic resonance imaging (MRI) when investigating abnormalities. Although BVM methods are widely used, they need to be evaluated to quantify their reliability. Currently, the gold-standard reference to evaluate a BVM is usually manual labeling measurement. Manual volume labeling is a time-consuming and expensive task, but the confidence level ascribed to this method is not absolute. We describe and evaluate a biomimetic brain phantom as an alternative for the manual validation of BVM. Methods: We printed a three-dimensional (3D) brain mold using an MRI of a three-year-old boy diagnosed with Sturge-Weber syndrome. Then we prepared three different mixtures of styrene-ethylene/butylene-styrene gel and paraffin to mimic white matter (WM), gray matter (GM), and cerebrospinal fluid (CSF). The mold was filled by these three mixtures with known volumes. We scanned the brain phantom using two MRI scanners, 1.5 and 3.0 Tesla. Our suggestion is a new challenging model to evaluate the BVM which includes the measured volumes of the phantom compartments and its MRI. We investigated the performance of an automatic BVM, i.e., the expectation–maximization (EM) method, to estimate its accuracy in BVM. Results: The automatic BVM results using the EM method showed a relative error (regarding the phantom volume) of 0.08, 0.03, and 0.13 (±0.03 uncertainty) percentages of the GM, CSF, and WM volume, respectively, which was in good agreement with the results reported using manual segmentation. Conclusions: The phantom can be a potential quantifier for a wide range of segmentation methods.
| Type: | Article |
|---|---|
| Title: | Biomimetic phantom with anatomical accuracy for evaluating brain volumetric measurements with magnetic resonance imaging |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1117/1.jmi.8.1.013503 |
| Publisher version: | https://doi.org/10.1117/1.jmi.8.1.013503 |
| Language: | English |
| Additional information: | This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | physical phantom; brain volume measurements; magnetic resonance imaging; evaluation method |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10177530 |
Archive Staff Only
 |
View Item |
