Kumar, Shankar;
Pollok, Richard;
Goldsmith, David;
(2022)
Renal and Urological Disorders Associated With Inflammatory Bowel Disease.
Inflammatory Bowel Diseases
, 29
(8)
pp. 1306-1316.
10.1093/ibd/izac140.
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Abstract
Renal and urinary tract complications related to inflammatory bowel disease (IBD) have been relatively understudied in the literature compared with other extraintestinal manifestations. Presentation of these renal manifestations can be subtle, and their detection is complicated by a lack of clarity regarding the optimal screening and routine monitoring of renal function in IBD patients. Urolithiasis is the most common manifestation. Penetrating Crohn's disease involving the genitourinary system as an extraintestinal complication is rare but associated with considerable morbidity. Some biologic agents used to treat IBD have been implicated in progressive renal impairment, although differentiating between drug-related side effects and deteriorating kidney function due to extraintestinal manifestations can be challenging. The most common findings on renal biopsy of IBD patients with renal injury are tubulointerstitial nephritis and IgA nephropathy, the former also being associated with drug-induced nephrotoxicity related to IBD medication. Amyloidosis, albeit rare, must be diagnosed early to reduce the chance of progression to renal failure. In this review, we evaluate the key literature relating to renal and urological involvement in IBD and emphasize the high index of suspicion required for the prompt diagnosis and treatment of these manifestations and complications, considering the potential severity and implications of acute or chronic loss of renal function. We also provide suggestions for future research priorities.
| Type: | Article |
|---|---|
| Title: | Renal and Urological Disorders Associated With Inflammatory Bowel Disease |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/ibd/izac140 |
| Publisher version: | https://doi.org/10.1093/ibd/izac140 |
| Language: | English |
| Additional information: | This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Gastroenterology & Hepatology, inflammatory bowel disease, Crohn's disease, ulcerative colitis, renal disease, extraintestinal manifestation, GRANULOMATOUS INTERSTITIAL NEPHRITIS, ULCERATIVE-COLITIS, IGA NEPHROPATHY, CROHNS-DISEASE, EXTRAINTESTINAL MANIFESTATIONS, TUBULOINTERSTITIAL NEPHRITIS, CONTRAST ULTRASONOGRAPHY, CLINICAL-FEATURES, INTERNAL FISTULAS, DOUBLE-BLIND |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10176841 |
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