Jung, Paul Gu-Yun;
(2023)
Trauma-induced threat-based mechanisms underlying psychosis.
Doctoral thesis (Ph.D), UCL (University College London).
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Abstract
There is growing evidence that developmental trauma is causally associated with an increased risk of psychosis. However, there is a striking lack of understanding of the precise mechanisms that underlie this association. Consistent with biopsychosocial and cognitive theories of psychosis, multiple lines of evidence converge on the role of threat processing in the pathway linking developmental trauma and psychosis. This thesis examined the effect of developmental trauma on threat processing and the neural structures underlying threat processing – the amygdala and ventromedial prefrontal cortex (vmPFC) - and examined their role in the association between developmental trauma and psychotic experiences. Using data from a systematic review and meta-analysis, three cross-sectional studies and one population-based cohort study, this thesis provides evidence that developmental trauma is associated with lasting alterations in threat processing and the brain structures underlying threat processing. These alterations in threat processing were associated with increased severity of psychotic experiences. Importantly, developmental trauma-associated alterations in threat processing played a mediating role in the relationship between developmental trauma and psychotic experiences. This thesis presents evidence suggesting neurobiological and cognitive mediators of the trauma-psychotic experience relationship and demonstrate that altered neural processing of threat may be target mechanisms for personalised therapies and for the secondary prevention of psychosis in adult survivors of developmental trauma.
| Type: | Thesis (Doctoral) |
|---|---|
| Qualification: | Ph.D |
| Title: | Trauma-induced threat-based mechanisms underlying psychosis |
| Open access status: | An open access version is available from UCL Discovery |
| Language: | English |
| Additional information: | Copyright © The Author 2023. Original content in this thesis is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) Licence (https://creativecommons.org/licenses/by-nc/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author’s request. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10176576 |
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