Bruno, D;
Jauregi Zinkunegi, A;
Kollmorgen, G;
Carboni, M;
Wild, N;
Carlsson, C;
Bendlin, B;
... Mueller, KD; + view all
(2023)
A comparison of diagnostic performance of word-list and story recall tests for biomarker-determined Alzheimer’s disease.
Journal of Clinical and Experimental Neuropsychology
pp. 1-7.
10.1080/13803395.2023.2240060.
(In press).
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Abstract
BACKGROUND: Wordlist and story recall tests are routinely employed in clinical practice for dementia diagnosis. In this study, our aim was to establish how well-standard clinical metrics compared to process scores derived from wordlist and story recall tests in predicting biomarker determined Alzheimer’s disease, as defined by CSF ptau/Aβ42 ratio. METHODS: Data from 295 participants (mean age = 65 ± 9.) were drawn from the University of Wisconsin – Madison Alzheimer’s Disease Research Center (ADRC) and Wisconsin Registry for Alzheimer’s Prevention (WRAP). Rey’s Auditory Verbal Learning Test (AVLT; wordlist) and Logical Memory Test (LMT; story) data were used. Bayesian linear regression analyses were carried out with CSF ptau/Aβ42 ratio as outcome. Sensitivity analyses were carried out with logistic regressions to assess diagnosticity. RESULTS: LMT generally outperformed AVLT. Notably, the best predictors were primacy ratio, a process score indexing loss of information learned early during test administration, and recency ratio, which tracks loss of recently learned information. Sensitivity analyses confirmed this conclusion. CONCLUSIONS: Our study shows that story recall tests may be better than wordlist tests for detection of dementia, especially when employing process scores alongside conventional clinical scores.
| Type: | Article |
|---|---|
| Title: | A comparison of diagnostic performance of word-list and story recall tests for biomarker-determined Alzheimer’s disease |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1080/13803395.2023.2240060 |
| Publisher version: | https://doi.org/10.1080/13803395.2023.2240060 |
| Language: | English |
| Additional information: | © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | Memory, dementia, story recall, biomarkers, serial position |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10176256 |
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