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Associations of inner retinal layers with risk of incident dementia: An individual participant data analysis of four prospective cohort studies

van der Heide, Frank CT; Khawaja, Anthony; Berendschot, Tos TJM; Littlejohns, Thomas J; Kuźma, Elżbieta; Luben, Robert; Patel, Praveen J; ... Stehouwer, Coen DA; + view all (2023) Associations of inner retinal layers with risk of incident dementia: An individual participant data analysis of four prospective cohort studies. Alzheimer's & Dementia 10.1002/alz.13167. (In press). Green open access

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Abstract

INTRODUCTION: Our main objective was to investigate whether retinal neurodegeneration, estimated from lower thickness of inner retinal layers, was associated with incident all-cause dementia and Alzheimer's disease (AD). METHODS: We performed an individual participant data meta-analysis using unpublished data from four prospective cohort studies with a total of 69,955 participants (n = 1087 cases of incident all-cause dementia; n = 520 cases incident AD; follow-up time median [interquartile range] 11.3 [8.8-11.5] years). RESULTS: General baseline characteristics of the study population were mean (standard deviation) age, 58.1 (8.8) years; 47% women. After adjustment, lower baseline macular retinal nerve fiber layer thickness was significantly associated with a 10% and 11% higher incidence of all-cause dementia and AD, respectively. Lower baseline macular ganglion cell-inner plexiform layer thickness was not significantly associated with these outcomes. DISCUSSION: These findings suggest that retinal neurodegeneration precedes the onset of clinical dementia. Retinal imaging tools may be informative biomarkers for the study of the early pathophysiology of dementia.

Type: Article
Title: Associations of inner retinal layers with risk of incident dementia: An individual participant data analysis of four prospective cohort studies
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/alz.13167
Publisher version: https://doi.org/10.1002/alz.13167
Language: English
Additional information: © 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Alzheimer's disease, E3 consortium, OCT, The Alienor Study, The Maastricht Study, The Tromsø Study, The UK Biobank, UK Biobank Eye & Vision Consortium, dementia, early-onset dementia cohort, epidemiology, frontotemporal dementia, optical coherence tomography, retinal imaging, retinal neurodegeneration, vascular dementia
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10175526
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