van der Heide, Frank CT;
Khawaja, Anthony;
Berendschot, Tos TJM;
Littlejohns, Thomas J;
Kuźma, Elżbieta;
Luben, Robert;
Patel, Praveen J;
... Stehouwer, Coen DA; + view all
(2023)
Associations of inner retinal layers with risk of incident dementia: An individual participant data analysis of four prospective cohort studies.
Alzheimer's & Dementia
10.1002/alz.13167.
(In press).
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Abstract
INTRODUCTION: Our main objective was to investigate whether retinal neurodegeneration, estimated from lower thickness of inner retinal layers, was associated with incident all-cause dementia and Alzheimer's disease (AD). METHODS: We performed an individual participant data meta-analysis using unpublished data from four prospective cohort studies with a total of 69,955 participants (n = 1087 cases of incident all-cause dementia; n = 520 cases incident AD; follow-up time median [interquartile range] 11.3 [8.8-11.5] years). RESULTS: General baseline characteristics of the study population were mean (standard deviation) age, 58.1 (8.8) years; 47% women. After adjustment, lower baseline macular retinal nerve fiber layer thickness was significantly associated with a 10% and 11% higher incidence of all-cause dementia and AD, respectively. Lower baseline macular ganglion cell-inner plexiform layer thickness was not significantly associated with these outcomes. DISCUSSION: These findings suggest that retinal neurodegeneration precedes the onset of clinical dementia. Retinal imaging tools may be informative biomarkers for the study of the early pathophysiology of dementia.
| Type: | Article |
|---|---|
| Title: | Associations of inner retinal layers with risk of incident dementia: An individual participant data analysis of four prospective cohort studies |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/alz.13167 |
| Publisher version: | https://doi.org/10.1002/alz.13167 |
| Language: | English |
| Additional information: | © 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | Alzheimer's disease, E3 consortium, OCT, The Alienor Study, The Maastricht Study, The Tromsø Study, The UK Biobank, UK Biobank Eye & Vision Consortium, dementia, early-onset dementia cohort, epidemiology, frontotemporal dementia, optical coherence tomography, retinal imaging, retinal neurodegeneration, vascular dementia |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10175526 |
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