Hileti, Dona;
Demetriou, Christiana A;
Iasonides, Michalis C;
Pipis, Spyros;
Mahmood, Amna;
Lanigan, Julie;
Singhal, Atul;
(2023)
Weight Gain in Early Infancy Impacts Appetite Regulation in the First Year of Life. A Prospective Study of Infants Living in Cyprus.
The Journal of Nutrition
, 153
(8)
pp. 2531-2539.
10.1016/j.tjnut.2023.06.017.
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Abstract
BACKGROUND: Eating behaviour is associated with weight gain in infancy and childhood. Few studies found a bi-directional association between weight gain and eating behaviour development in childhood but there is little data on the association in early infancy, a period critical for the programming of obesity risk. OBJECTIVE: We investigated the bi-directional association between appetite traits and weight gain during the first year of life. METHODS: Participants were part of a cohort of 432 infants born in Cyprus. Appetite traits were measured using the BEBQ or the CEBQ at age 2-4 weeks, 6 and 12 months. Weight and length were collected at birth, 4 weeks, 6 and 12 months. Multivariable linear regression was used to analyse associations between appetite traits at 2-4 weeks and 6 months and weight for age Z-score change (WFAZC) between 4 weeks-6 months and 6-12 months. Associations were also analysed in the opposite direction, between WFAZC from birth to 4 weeks, 4 weeks to 6 months, 6-12 months and appetite traits at 4 weeks, 6 months and 12 months. RESULTS: Satiety responsive (SR) at 2-4 weeks was associated with lower WFAZC from 4 weeks to 6 months (β=-0.17; 95%CI: -0.30, -0.04) and SR at age 6 months was associated with lower WFAZC from 6 to 12 months (β=-0.09; 95%CI: -0.17, -0.02). WFAZC from 4 weeks to 6 months was associated with higher EF at 12 months (β=0.11; 95%CI: 0.01, 0.20), higher FR at 12 months (β=0.17; 95%CI: 0.04, 0.30) and lower SR at both 6 (β=-0.11; 95%CI: -0.21, -0.01) and 12 months (β=-0.14; 95%CI: -0.24, -0.03) CONCLUSIONS: We found a bi-directional association between weight gain and appetite traits in infancy, suggesting that the effect of postnatal weight gain on obesity development is partly mediated by programming of appetite traits.
| Type: | Article |
|---|---|
| Title: | Weight Gain in Early Infancy Impacts Appetite Regulation in the First Year of Life. A Prospective Study of Infants Living in Cyprus |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.tjnut.2023.06.017 |
| Publisher version: | https://doi.org/10.1016/j.tjnut.2023.06.017 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| Keywords: | eating behavior, ΒΕΒQ (Baby Eating Behavior Questionnaire), CEBQ (Child Eating Behavior Questionnaire), appetite, infant growth, childhood obesity, cohort studies |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10173239 |
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