Harlianto, NI;
Westerink, J;
Hol, ME;
Wittenberg, R;
Foppen, W;
Van Der Veen, PH;
Van Ginneken, B;
... Visseren, FLJ; + view all
(2022)
Patients with diffuse idiopathic skeletal hyperostosis have an increased burden of thoracic aortic calcifications.
Rheumatology Advances in Practice
, 6
(2)
, Article rkac060. 10.1093/rap/rkac060.
Preview |
PDF
Asselbergs_Patients with diffuse idiopathic skeletal hyperostosis have an increased burden of thoracic aortic calcifications_VoR.pdf - Published Version Download (2MB) | Preview |
Abstract
OBJECTIVES: DISH has been associated with increased coronary artery calcifications and incident ischaemic stroke. The formation of bone along the spine may share pathways with calcium deposition in the aorta. We hypothesized that patients with DISH have increased vascular calcifications. Therefore we aimed to investigate the presence and extent of DISH in relation to thoracic aortic calcification (TAC) severity. METHODS: This cross-sectional study included 4703 patients from the Second Manifestation of ARTerial disease cohort, consisting of patients with cardiovascular events or risk factors for cardiovascular disease. Chest radiographs were scored for DISH using the Resnick criteria. Different severities of TAC were scored arbitrarily from no TAC to mild, moderate or severe TAC. Using multivariate logistic regression, the associations between DISH and TAC were analysed with adjustments for age, sex, BMI, diabetes, smoking status, non-high-density lipoprotein cholesterol, cholesterol lowering drug usage, renal function and blood pressure. RESULTS: A total of 442 patients (9.4%) had evidence of DISH and 1789 (38%) patients had TAC. The prevalence of DISH increased from 6.6% in the no TAC group to 10.8% in the mild, 14.3% in the moderate and 17.1% in the severe TAC group. After adjustments, DISH was significantly associated with the presence of TAC [odds ratio (OR) 1.46 [95% CI 1.17, 1.82)]. In multinomial analyses, DISH was associated with moderate TAC [OR 1.43 (95% CI 1.06, 1.93)] and severe TAC [OR 1.67 (95% CI 1.19, 2.36)]. CONCLUSIONS: Subjects with DISH have increased TACs, providing further evidence that patients with DISH have an increased burden of vascular calcifications.
| Type: | Article |
|---|---|
| Title: | Patients with diffuse idiopathic skeletal hyperostosis have an increased burden of thoracic aortic calcifications |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/rap/rkac060 |
| Publisher version: | https://doi.org/10.1093/rap/rkac060 |
| Language: | English |
| Additional information: | © The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Rheumatology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). |
| Keywords: | atherosclerosis, bone formation, calcification, diffuse idiopathic skeletal hyperostosis, thoracic aortic calcification |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Health Informatics UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Health Informatics > Clinical Epidemiology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10173144 |
Archive Staff Only
 |
View Item |
