Trotta, Giulia;
Rodriguez, Victoria;
Quattrone, Diego;
Spinazzola, Edoardo;
Tripoli, Giada;
Gayer-Anderson, Charlotte;
Freeman, Tom P;
... Di Forti, Marta; + view all
(2023)
Cannabis use as a potential mediator between childhood adversity and first-episode psychosis: results from the EU-GEI case-control study.
Psychological Medicine
10.1017/S0033291723000995.
(In press).
Preview |
PDF
cannabis-use-as-a-potential-mediator-between-childhood-adversity-and-first-episode-psychosis-results-from-the-eu-gei-case-control-study.pdf - Published Version Download (421kB) | Preview |
Abstract
Background Childhood adversity and cannabis use are considered independent risk factors for psychosis, but whether different patterns of cannabis use may be acting as mediator between adversity and psychotic disorders has not yet been explored. The aim of this study is to examine whether cannabis use mediates the relationship between childhood adversity and psychosis. Methods Data were utilised on 881 first-episode psychosis patients and 1231 controls from the European network of national schizophrenia networks studying Gene–Environment Interactions (EU-GEI) study. Detailed history of cannabis use was collected with the Cannabis Experience Questionnaire. The Childhood Experience of Care and Abuse Questionnaire was used to assess exposure to household discord, sexual, physical or emotional abuse and bullying in two periods: early (0–11 years), and late (12–17 years). A path decomposition method was used to analyse whether the association between childhood adversity and psychosis was mediated by (1) lifetime cannabis use, (2) cannabis potency and (3) frequency of use. Results The association between household discord and psychosis was partially mediated by lifetime use of cannabis (indirect effect coef. 0.078, s.e. 0.022, 17%), its potency (indirect effect coef. 0.059, s.e. 0.018, 14%) and by frequency (indirect effect coef. 0.117, s.e. 0.038, 29%). Similar findings were obtained when analyses were restricted to early exposure to household discord. Conclusions Harmful patterns of cannabis use mediated the association between specific childhood adversities, like household discord, with later psychosis. Children exposed to particularly challenging environments in their household could benefit from psychosocial interventions aimed at preventing cannabis misuse.
| Type: | Article |
|---|---|
| Title: | Cannabis use as a potential mediator between childhood adversity and first-episode psychosis: results from the EU-GEI case-control study |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1017/S0033291723000995 |
| Publisher version: | https://doi.org/10.1017/S0033291723000995 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Social Sciences, Science & Technology, Life Sciences & Biomedicine, Psychology, Clinical, Psychiatry, Psychology, Cannabis use, childhood experience, mediation, psychotic disorders, trauma, SEXUAL-ABUSE, RISK, TRAUMA, ASSOCIATION, SYMPTOMS, METAANALYSIS, EXPERIENCES, DISORDERS, INCREASE, IMPACT |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry > Epidemiology and Applied Clinical Research |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10172951 |
Archive Staff Only
 |
View Item |
