Milighetti, Martina;
Peng, Yanchun;
Tan, Cedric;
Mark, Michal;
Nageswaran, Gayathri;
Byrne, Suzanne;
Ronel, Tahel;
... Chain, Benny; + view all
(2023)
Large clones of pre-existing T cells drive early immunity against SARS-COV-2 and LCMV infection.
iScience
, 26
(6)
, Article 106937. 10.1016/j.isci.2023.106937.
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Abstract
T cell responses precede antibody and may provide early control of infection. We analyzed the clonal basis of this rapid response following SARS-COV-2 infection. We applied T cell receptor (TCR) sequencing to define the trajectories of individual T cell clones immediately. In SARS-COV-2 PCR+ individuals, a wave of TCRs strongly but transiently expand, frequently peaking the same week as the first positive PCR test. These expanding TCR CDR3s were enriched for sequences functionally annotated as SARS-COV-2 specific. Epitopes recognized by the expanding TCRs were highly conserved between SARS-COV-2 strains but not with circulating human coronaviruses. Many expanding CDR3s were present at high frequency in pre-pandemic repertoires. Early response TCRs specific for lymphocytic choriomeningitis virus epitopes were also found at high frequency in the preinfection naive repertoire. High-frequency naive precursors may allow the T cell response to respond rapidly during the crucial early phases of acute viral infection.
| Type: | Article |
|---|---|
| Title: | Large clones of pre-existing T cells drive early immunity against SARS-COV-2 and LCMV infection |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.isci.2023.106937 |
| Publisher version: | https://doi.org/10.1016/j.isci.2023.106937 |
| Language: | English |
| Additional information: | © 2023 The Author(s). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Biological sciences, Cell biology, Immunity, Immunology |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10171396 |
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