Wang, Yujiang;
Schroeder, Gabrielle M;
Horsley, Jonathan J;
Panagiotopoulou, Mariella;
Chowdhury, Fahmida A;
Diehl, Beate;
Duncan, John S;
... Taylor, Peter N; + view all
(2023)
Temporal stability of intracranial electroencephalographic abnormality maps for localizing epileptogenic tissue.
Epilepsia
, 64
(8)
pp. 2070-2080.
10.1111/epi.17663.
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Abstract
Objective: Identifying abnormalities on interictal intracranial electroencephalogram (iEEG), by comparing patient data to a normative map, has shown promise for the localization of epileptogenic tissue and prediction of outcome. The approach typically uses short interictal segments of approximately 1 min. However, the temporal stability of findings has not been established.// Methods: Here, we generated a normative map of iEEG in nonpathological brain tissue from 249 patients. We computed regional band power abnormalities in a separate cohort of 39 patients for the duration of their monitoring period (.92–8.62 days of iEEG data, mean = 4.58 days per patient, >4800 hours recording). To assess the localizing value of band power abnormality, we computed DRS-a measure of how different the surgically resected and spared tissue was in terms of band power abnormalities—over time.// Results: In each patient, the DRS value was relatively consistent over time. The median DRS of the entire recording period separated seizure-free (International League Against Epilepsy [ILAE] = 1) and not-seizure-free (ILAE 1) patients well (area under the curve [AUC] = .69). This effect was similar interictally (AUC = .69) and peri-ictally (AUC = .71).// Significance: Our results suggest that band power abnormality D_RS, as a predictor of outcomes from epilepsy surgery, is a relatively robust metric over time. These findings add further support for abnormality mapping of neurophysiology data during presurgical evaluation.
| Type: | Article |
|---|---|
| Title: | Temporal stability of intracranial electroencephalographic abnormality maps for localizing epileptogenic tissue |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/epi.17663 |
| Publisher version: | https://doi.org/10.1111/epi.17663 |
| Language: | English |
| Additional information: | © 2023 The Authors. Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10170965 |
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