Coath, William;
Modat, Marc;
Cardoso, M Jorge;
Markiewicz, Pawel J;
Lane, Christopher A;
Parker, Thomas D;
Keshavan, Ashvini;
... Alzheimer's Disease Neuroimaging Initiative; + view all
(2023)
Operationalizing the centiloid scale for [18F]florbetapir PET studies on PET/MRI.
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
, 15
(2)
, Article e12434. 10.1002/dad2.12434.
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Coath_Alz Dem Diag Ass Dis Mo -_2023 - Coath - Operationalizing the centiloid scale for 18F florbetapir PET studies on PET.pdf Download (1MB) | Preview |
Abstract
INTRODUCTION: The Centiloid scale aims to harmonize amyloid beta (Aβ) positron emission tomography (PET) measures across different analysis methods. As Centiloids were created using PET/computerized tomography (CT) data and are influenced by scanner differences, we investigated the Centiloid transformation with data from Insight 46 acquired with PET/magnetic resonanceimaging (MRI). METHODS: We transformed standardized uptake value ratios (SUVRs) from 432 florbetapir PET/MRI scans processed using whole cerebellum (WC) and white matter (WM) references, with and without partial volume correction. Gaussian-mixture-modelling-derived cutpoints for Aβ PET positivity were converted. RESULTS: The Centiloid cutpoint was 14.2 for WC SUVRs. The relationship between WM and WC uptake differed between the calibration and testing datasets, producing implausibly low WM-based Centiloids. Linear adjustment produced a WM-based cutpoint of 18.1. DISCUSSION: Transformation of PET/MRI florbetapir data to Centiloids is valid. However, further understanding of the effects of acquisition or biological factors on the transformation using a WM reference is needed.
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