Coerver, EME;
Janssens, S;
Ahmed, A;
Wessels, MHJ;
Van Kempen, ZLE;
Jasperse, MMS;
Barkhof, F;
... Strijbis, EMM; + view all
(2023)
The association between age and inflammatory disease activity on MRI in relapse-onset multiple sclerosis during long-term follow-up.
European Journal of Neurology
, 30
(8)
pp. 2385-2392.
10.1111/ene.15862.
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Abstract
BACKGROUND: Inflammatory disease activity in multiple sclerosis (MS) decreases with advancing age. Previous work found a decrease in contrast enhancing lesions (CELs) with age. Here we describe the relation of age and MRI measures of inflammatory disease activity during long-term follow-up in a large real-world cohort of people with relapse-onset MS. METHODS: We investigated MRI data from the long-term observational Amsterdam MS cohort. We used logistic regression models and negative binomial generalized estimating equations to investigate the associations between age and radiological disease activity after a first clinical event. RESULTS: We included 1,063 participants, and 10,651 cranial MRIs. Median follow-up time was 6.1 years (IQR 2.4-10.9 years). Older participants had a significantly lower risk of CELs on baseline MRI (40-50 years vs. <40 years: OR=0.640, 95%CI 0.45-0.90, >50 years vs. <40 years: OR=0.601, 95%CI 0.33-1.08), and a lower risk of new T2-lesions or CELs during follow-up (40-50 years vs. <40 years: OR=0.563, 95%CI 0.47-0.67, >50 years vs. <40 years: OR=0.486, 95%CI 0.35-0.68). CONCLUSIONS: Higher age is associated with a lower risk of inflammatory MRI activity at baseline and during long-term follow-up. In patients aged >50 years, a less aggressive treatment strategy might be appropriate compared to younger patients.
| Type: | Article |
|---|---|
| Title: | The association between age and inflammatory disease activity on MRI in relapse-onset multiple sclerosis during long-term follow-up |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/ene.15862 |
| Publisher version: | http://doi.org/10.1111/ene.15862 |
| Language: | English |
| Additional information: | Copyright © 2023 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| Keywords: | demyelinating disease, MRI, multiple sclerosis |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10170027 |
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