Moyaert, Paulien;
Padrela, Beatriz E;
Morgan, Catherine A;
Petr, Jan;
Versijpt, Jan;
Barkhof, Frederik;
Jurkiewicz, Michael T;
... Anazodo, Udunna C; + view all
(2023)
Imaging blood-brain barrier dysfunction: A state-of-the-art review from a clinical perspective.
Frontiers in Aging Neuroscience
, 15
, Article 1132077. 10.3389/fnagi.2023.1132077.
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Abstract
The blood-brain barrier (BBB) consists of specialized cells that tightly regulate the in- and outflow of molecules from the blood to brain parenchyma, protecting the brain's microenvironment. If one of the BBB components starts to fail, its dysfunction can lead to a cascade of neuroinflammatory events leading to neuronal dysfunction and degeneration. Preliminary imaging findings suggest that BBB dysfunction could serve as an early diagnostic and prognostic biomarker for a number of neurological diseases. This review aims to provide clinicians with an overview of the emerging field of BBB imaging in humans by answering three key questions: (1. Disease) In which diseases could BBB imaging be useful? (2. Device) What are currently available imaging methods for evaluating BBB integrity? And (3. Distribution) what is the potential of BBB imaging in different environments, particularly in resource limited settings? We conclude that further advances are needed, such as the validation, standardization and implementation of readily available, low-cost and non-contrast BBB imaging techniques, for BBB imaging to be a useful clinical biomarker in both resource-limited and well-resourced settings.
| Type: | Article |
|---|---|
| Title: | Imaging blood-brain barrier dysfunction: A state-of-the-art review from a clinical perspective |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fnagi.2023.1132077 |
| Publisher version: | https://doi.org/10.3389/fnagi.2023.1132077 |
| Language: | English |
| Additional information: | Copyright © 2023 Moyaert, Padrela, Morgan, Petr, Versijpt, Barkhof, Jurkiewicz, Shao, Oyeniran, Manson, Wang, Günther, Achten, Mutsaerts and Anazodo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | blood-brain barrier dysfunction, diagnostic imaging, magnetic resonance imaging, neurodegeneration, positron emission tomography |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10169923 |
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