Hong, J;
Brendel, M;
Erlandsson, K;
Sari, H;
Lu, J;
Clement, C;
Bui, NV;
... Shi, K; + view all
(2023)
Forecasting the Pharmacokinetics With Limited Early Frames in Dynamic Brain PET Imaging Using Neural Ordinary Differential Equation.
IEEE Transactions on Radiation and Plasma Medical Sciences
, 7
(6)
pp. 607-617.
10.1109/TRPMS.2023.3253261.
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Abstract
In dynamic brain positron emission tomography (PET) studies, acquiring a time series of images, typically lasting more than an hour, is necessary to derive pharmacokinetic parameters. Analytically, these parameters are estimated by establishing kinetic models such as compartment models that consist of sets of ordinary differential equations (ODE), and by fitting the sparse time-activity curve (TAC) of the tracer. Yet, these models are simplified approximations of highly complex underlying processes, and sufficient samples of TAC are required throughout the entire acquisition, which is not only impractical but also hindered by patient involuntary motion and intrinsic noise. Therefore, recovering samples in missing timeframes is often required, which, in practice, is achieved by interpolation or extrapolation. Here, we introduce a novel deep-learning-based method that utilizes neural ODE (N-ODE) to predict TAC in the extended timeframes by mimicking analytical method in a data-driven manner. By training N-ODE to solve and fit sets of ODE such that the solution replicates the observed TAC, the N-ODE converges to the functional shapes that best describe the underlying pharmacokinetic processes. We customized N-ODE to predict the full-dynamic images (12 frames, 60min), hence pharmacokinetic parameters, given limited early-frame images (7 to 9 frames, 20 to 30min). For proof of concept, the proposed N-ODE was applied to simulated and clinical 18F-PI-2620 brain PET. We demonstrated that the proposed N-ODE delivered promising performance, indicated by bias, variance, and mean absolute error as well as pharmacokinetic parameters such as rate constants, standardized uptake value ratio (SUVr), and binding potential (BPND).
| Type: | Article |
|---|---|
| Title: | Forecasting the Pharmacokinetics With Limited Early Frames in Dynamic Brain PET Imaging Using Neural Ordinary Differential Equation |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1109/TRPMS.2023.3253261 |
| Publisher version: | https://doi.org/10.1109/TRPMS.2023.3253261 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Positron emission tomography, Protocols, Mathematical models, Data models, Brain modeling, Analytical models, Nuclear medicine |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10169869 |
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