Meir, Amit;
Macé, Kévin;
Vegunta, Yogesh;
Williams, Sunanda M;
Waksman, Gabriel;
(2023)
Substrate recruitment mechanism by gram-negative type III, IV, and VI bacterial injectisomes.
Trends in Microbiology
10.1016/j.tim.2023.03.005.
(In press).
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Abstract
Bacteria use a wide arsenal of macromolecular substrates (DNA and proteins) to interact with or infect prokaryotic and eukaryotic cells. To do so, they utilize substrate-injecting secretion systems or injectisomes. However, prior to secretion, substrates must be recruited to specialized recruitment platforms and then handed over to the secretion apparatus for secretion. In this review, we provide an update on recent advances in substrate recruitment and delivery by gram-negative bacterial recruitment platforms associated with Type III, IV, and VI secretion systems.
| Type: | Article |
|---|---|
| Title: | Substrate recruitment mechanism by gram-negative type III, IV, and VI bacterial injectisomes |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.tim.2023.03.005 |
| Publisher version: | http://doi.org/10.1016/j.tim.2023.03.005 |
| Language: | English |
| Additional information: | © 2023 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | bacteria, secretion system, injectisome, T3SS, T4SS, T6SS, substrate recruitment |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10168977 |
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