Nai, YH;
Wang, X;
Gan, J;
Lian, CPL;
Kirwan, RF;
Tan, FSL;
Hausenloy, DJ;
(2023)
Effects of fitting methods, high b-values and image quality on diffusion and perfusion quantification and reproducibility in the calf.
Computers in Biology and Medicine
, 157
, Article 106746. 10.1016/j.compbiomed.2023.106746.
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Abstract
Purposes: The study aimed to optimize diffusion-weighted imaging (DWI) image acquisition and analysis protocols in calf muscles by investigating the effects of different model-fitting methods, image quality, and use of high b-value and constraints on parameters of interest (POIs). The optimized modeling methods were used to select the optimal combinations of b-values, which will allow shorter acquisition time while achieving the same reliability as that obtained using 16 b-values. Methods: Test-retest baseline and high-quality DWI images of ten healthy volunteers were acquired on a 3T MR scanner, using 16 b-values, including a high b-value of 1200 s/mm2, and structural T1-weighted images for calf muscle delineation. Three and six different fitting methods were used to derive ADC from monoexponential (ME) model and Dd, fp, and Dp from intravoxel incoherent motion (IVIM) model, with or without the high b-value. The optimized ME and IVIM models were then used to determine the optimal combinations of b-values, obtainable with the least number of b-values, using the selection criteria of coefficient of variance (CV) ≤10% for all POIs. Results: The find minimum multivariate algorithm was more flexible and yielded smaller fitting errors. The 2-steps fitting method, with fixed Dd, performed the best for IVIM model. The inclusion of high b-value reduced outliers, while constraints improved 2-steps fitting only. Conclusions: The optimal numbers of b-values for ME and IVIM models were nine and six b-values respectively. Test-retest reliability analyses showed that only ADC and Dd were reliable for calf diffusion evaluation, with CVs of 7.22% and 4.09%.
| Type: | Article |
|---|---|
| Title: | Effects of fitting methods, high b-values and image quality on diffusion and perfusion quantification and reproducibility in the calf |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.compbiomed.2023.106746 |
| Publisher version: | https://doi.org/10.1016/j.compbiomed.2023.106746 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Technology, Biology, Computer Science, Interdisciplinary Applications, Engineering, Biomedical, Mathematical & Computational Biology, Life Sciences & Biomedicine - Other Topics, Computer Science, Engineering, Diffusion-weighted imaging (DWI), Intravoxel incoherent motion (IVIM), Monoexponential (ME), Calf muscles, Model fitting, Reliability, INTRAVOXEL INCOHERENT MOTION, MRI, COEFFICIENTS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10168669 |
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