Yong, Hannah Ee Juen;
Maksym, Katarzyna;
Yusoff, Muhammad Ashraf Bin;
Salazar-Petres, Esteban;
Nazarenko, Tatiana;
Zaikin, Alexey;
David, Anna L;
... Sferruzzi-Perri, Amanda N; + view all
(2023)
Integrated Placental Modelling of Histology with Gene Expression to Identify Functional Impact on Fetal Growth.
Cells
, 12
(7)
, Article 1093. 10.3390/cells12071093.
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Abstract
Fetal growth restriction (FGR) is a leading cause of perinatal morbidity and mortality. Altered placental formation and functional capacity are major contributors to FGR pathogenesis. Relating placental structure to function across the placenta in healthy and FGR pregnancies remains largely unexplored but could improve understanding of placental diseases. We investigated integration of these parameters spatially in the term human placenta using predictive modelling. Systematic sampling was able to overcome heterogeneity in placental morphological and molecular features. Defects in villous development, elevated fibrosis, and reduced expression of growth and functional marker genes (IGF2, VEGA, SLC38A1, and SLC2A3) were seen in age-matched term FGR versus healthy control placentas. Characteristic histopathological changes with specific accompanying molecular signatures could be integrated through computational modelling to predict if the placenta came from a healthy or FGR pregnancy. Our findings yield new insights into the spatial relationship between placental structure and function and the etiology of FGR.
| Type: | Article |
|---|---|
| Title: | Integrated Placental Modelling of Histology with Gene Expression to Identify Functional Impact on Fetal Growth |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/cells12071093 |
| Publisher version: | https://doi.org/10.3390/cells12071093 |
| Language: | English |
| Additional information: | © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| Keywords: | placenta; FGR; modelling; morphology; growth genes; transport |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Maternal and Fetal Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Womens Cancer |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10168331 |
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