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Targeting G-CSF to treat autoinflammation

Bunney, Tom D; Katan, Matilda; (2023) Targeting G-CSF to treat autoinflammation. Nature Immunology , 24 pp. 736-737. 10.1038/s41590-023-01474-5. Green open access

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Abstract

APLAID is a very rare autoinflammatory disease thought to be caused by mutations in PLCG2. A mouse model of APLAID recapitulates clinical features of the disease, and identifies a crucial function for G-CSF that might be targeted therapeutically.

Type: Article
Title: Targeting G-CSF to treat autoinflammation
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41590-023-01474-5
Publisher version: https://doi.org/10.1038/s41590-023-01474-5
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Cytokines, Inflammation, Inflammatory diseases
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10167824
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