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Brain Shrinkage in Anti-β-Amyloid Alzheimer Trials: Neurodegeneration or Pseudo-atrophy?

Barkhof, Frederik; Knopman, David S; (2023) Brain Shrinkage in Anti-β-Amyloid Alzheimer Trials: Neurodegeneration or Pseudo-atrophy? Neurology , 100 (20) pp. 941-942. 10.1212/WNL.0000000000207268. Green open access

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Abstract

One of the puzzling observations from anti–amyloid-β therapeutic trials for Alzheimer disease (AD) has been that treated arms fail to show preservation of brain volume. In this issue of Neurology®, Alves et al. presented a meta-analysis of anti–amyloid-β therapies and show that the agents do not slow the rate of brain volume loss. Depending on the class of drug, these new agents can even accelerate loss of whole-brain and hippocampal volume and increase ventricular volume. This association has been seen with some of the beta-secretase inhibitors and with several of the antiamyloid monoclonal antibodies.

Type: Article
Title: Brain Shrinkage in Anti-β-Amyloid Alzheimer Trials: Neurodegeneration or Pseudo-atrophy?
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1212/WNL.0000000000207268
Publisher version: https://doi.org/10.1212/WNL.0000000000207268
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
URI: https://discovery.ucl.ac.uk/id/eprint/10167722
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