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Rhodium-Catalyzed Cascade Reactions of Indoles with 4- Hydroxy-2-Alkynoates for the Synthesis of Indole-Fused Polyheterocycles

Wu, Xiaowei; Li, Pinyi; Lu, Yangbin; Qiao, Jin; Zhao, Jingwei; Jia, Xiuwen; Ni, Hangcheng; ... Zhao, Fei; + view all (2020) Rhodium-Catalyzed Cascade Reactions of Indoles with 4- Hydroxy-2-Alkynoates for the Synthesis of Indole-Fused Polyheterocycles. Advanced Synthesis & Catalysis (ASC) , 362 (14) pp. 2953-2960. 10.1002/adsc.202000493. Green open access

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Abstract

Herein, an efficient and regioselective Rh(III)-catalyzed [4+2] annulation/lactonization cascade of indoles with 4-hydroxy-2-alkynoates at room temperature to access the furo[3′,4′:4,5]pyrimido[1,6-a]indole-1,5(3H,4H)-diones is described. This method features mild reaction conditions, operational simplicity, excellent regioselectivity, broad substrate scope with good functional group tolerance, and good to excellent yields.

Type: Article
Title: Rhodium-Catalyzed Cascade Reactions of Indoles with 4- Hydroxy-2-Alkynoates for the Synthesis of Indole-Fused Polyheterocycles
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/adsc.202000493
Publisher version: https://doi.org/10.1002/adsc.202000493
Language: English
Additional information: This version is the author-accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Rhodium; CH activation; Cascadereaction; [4+2] annulation; Lactonization
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/10167672
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