Mofokeng, N;
Maponga, TG;
van Schalkwyk, M;
Hugo, S;
Morobadi, MD;
Vawda, S;
Badenhorst, L;
... Matthews, PC; + view all
(2023)
Barriers that prevent adults living with HBV infection from participating in clinical research: experience from South Africa.
Journal of Virus Eradication
, 9
(1)
, Article 100317. 10.1016/j.jve.2023.100317.
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Abstract
High profile international goals have been set for the elimination of hepatitis B virus (HBV) infection as a public health threat by the year 2030. Developing and expanding equitable, accessible translational HBV research programmes that represent real-world populations are therefore an urgent priority for clinical and academic communities. We present experiences and insights by an expert interdisciplinary group focusing on barriers that impede adults living with HBV infection from participating in clinical studies. Our viewpoint describes barriers we have identified through working in a variety of settings across South Africa, including lack of education and awareness, experiences of stigma and discrimination, challenges for governance and data management, and a burden of complex morbidity. Through identifying these challenges, we propose solutions and interventions, highlight new approaches, and provide a framework for future research.
| Type: | Article |
|---|---|
| Title: | Barriers that prevent adults living with HBV infection from participating in clinical research: experience from South Africa |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jve.2023.100317 |
| Publisher version: | https://doi.org/10.1016/j.jve.2023.100317 |
| Language: | English |
| Additional information: | © 2023 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Hepatitis B virus, HBV, Clinical research, Trials, Ethics, Barriers, Elimination, Equity, South Africa, LMIC |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10166912 |
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