Lim, Kai Xiang;
Oginni, Olakunle Ayokunmi;
Rimfeld, Kaili;
Pingault, Jean-Baptiste;
Rijsdijk, Frühling;
(2022)
Investigating the causal risk factors for self-harm by integrating Mendelian randomisation within twin modelling.
Behavior Genetics
, 52
pp. 324-337.
10.1007/s10519-022-10114-x.
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Abstract
Previous genetically informed studies have uncovered likely causal relationships between mental health problems and self-harm but resulting causal estimates may be biased due to unmediated pleiotropy. By fitting Mendelian Randomization - Direction of Causation (MR-DoC) models that explicitly model pleiotropy, we investigated the effect of four quantitatively measured mental health problems - major depressive disorder (MDD), schizophrenia, attention-deficit hyperactivity disorder (ADHD), and insomnia, on non-suicidal self-harm (NSSH) and suicidal self-harm (SSH), separately. We used data of 12,723 twins (56.6% females) in the Twins Early Development Study. Besides substantial pleiotropy, we found effects from child-rated depressive symptoms to both NSSH (β=0.194, 95% CIs: 0.131, 0.257) and SSH (β=0.210, 95% CIs: 0.125, 0.295). Similarly, effects flowed from parent-rated depressive symptoms to NSSH (β=0.092, 95% CIs: 0.004, 0.181) and SSH (β=0.165, 95% CIs: 0.051, 0.281). We did not find evidence of aetiological difference between NSSH and SSH.
| Type: | Article |
|---|---|
| Title: | Investigating the causal risk factors for self-harm by integrating Mendelian randomisation within twin modelling |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s10519-022-10114-x |
| Publisher version: | https://doi.org/10.1007/s10519-022-10114-x |
| Language: | English |
| Additional information: | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit (http://creativecommons. org/licenses/by/4.0/). |
| Keywords: | Mental health, Mendelian randomisation, Direction of Causation, MR-DoC, suicidal self-harm, nonsuicidal self-harm |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10166480 |
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