Hebden, Jeremy C;
Fu, Yihong;
Pacis, Danica M;
(2023)
Derivation of chromophore concentrations in turbid media using the rate of change of optical attenuation with respect to wavelength.
Optics Continuum
, 2
(3)
, Article 616. 10.1364/optcon.477701.
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Abstract
A spectroscopic method is investigated for estimating the concentrations of absorbers in highly scattering media using measurements of the rate of change of optical attenuation with wavelength. Such measurements are independent of absolute intensity and thus may be significantly less influenced by changes in coupling which often cause artefacts in medical applications of near-infrared spectroscopy. The method has been explored using a combination of stochastic (Monte Carlo) and analytical (diffusion-based) models and experiments on samples of turbid fluids. Results suggest that the method is highly tolerant of changes in the measurement geometry. The accuracy of the derived concentrations of absorbers can be strongly influenced by the wavelength dependence of scattering, and an ad-hoc, empirically-derived correction for this dependency has been investigated and implemented with some success.
| Type: | Article |
|---|---|
| Title: | Derivation of chromophore concentrations in turbid media using the rate of change of optical attenuation with respect to wavelength |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1364/optcon.477701 |
| Publisher version: | http://dx.doi.org/10.1364/optcon.477701 |
| Language: | English |
| Additional information: | This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10166424 |
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