Gater, Deborah L;
Hughes, Keontré I;
Stojanoff, Vivian;
Isakovic, Abdel F;
(2023)
Phase Heterogeneity in Cholesterol-Containing Ternary Phospholipid Lamellar Phases.
ACS Omega
, 8
(7)
pp. 6225-6233.
10.1021/acsomega.2c04914.
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Abstract
Pseudo-ternary mixtures of lamellar phase phospholipids (DPPC and brain sphingomyelin with cholesterol) were studied below T m while comparing the influence of cholesterol content, temperature, and the presence of small quantities of vitamin D binding protein (DBP) or vitamin D receptor (VDR). The measurements, conducted by X-ray diffraction (XRD) and nuclear magnetic resonance (NMR), cover a range of cholesterol concentrations (20% mol. wt to 40% mol. wt.) and physiologically relevant temperature range (294-314 K). In addition to rich intraphase behavior, data and modeling are used to approximate the lipids' headgroup location variations under the abovementioned experimental conditions.
| Type: | Article |
|---|---|
| Title: | Phase Heterogeneity in Cholesterol-Containing Ternary Phospholipid Lamellar Phases |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1021/acsomega.2c04914 |
| Publisher version: | https://doi.org/10.1021/acsomega.2c04914 |
| Language: | English |
| Additional information: | © 2023 The Authors. Published by American Chemical Society. This is an open access article under the CC BY 4.0 license Attribution 4.0 International (https://creativecommons.org/licenses/by/4.0/) |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Education UCL > Provost and Vice Provost Offices > School of Education > UCL Institute of Education UCL > Provost and Vice Provost Offices > School of Education > UCL Institute of Education > Centre for Languages and Intl Educatn |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10165777 |
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