Weiler, Simon;
Krinner, Stefanie;
Wong, Aaron B;
Moser, Tobias;
Pangršič, Tina;
(2014)
ATP Hydrolysis Is Critically Required for Function of Caᵥ1.3 Channels in Cochlear Inner Hair Cells via Fueling Ca²⁺ Clearance.
The Journal of Neuroscience
, 34
(20)
pp. 6843-6848.
10.1523/JNEUROSCI.4990-13.2014.
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Weiler et al. 2014 ATP hydrolysis is critically required for function of Cav1.3 channels in cochlear inner hair cells via fueling Ca2+ clearance.pdf - Published Version Download (415kB) | Preview |
Abstract
Sound encoding is mediated by Ca²⁺ influx-evoked release of glutamate at the ribbon synapse of inner hair cells. Here we studied the role of ATP in this process focusing on Ca²⁺ current through Caᵥ1.3 channels and Ca²⁺ homeostasis in mouse inner hair cells. Patch-clamp recordings and Ca²⁺ imaging demonstrate that hydrolyzable ATP is essential to maintain synaptic Ca²⁺ influx in inner hair cells via fueling Ca²⁺-ATPases to avoid an increase in cytosolic [Ca²⁺] and subsequent Ca²⁺/calmodulin-dependent inactivation of Caᵥ1.3 channels.
| Type: | Article |
|---|---|
| Title: | ATP Hydrolysis Is Critically Required for Function of Caᵥ1.3 Channels in Cochlear Inner Hair Cells via Fueling Ca²⁺ Clearance |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1523/JNEUROSCI.4990-13.2014 |
| Publisher version: | https://doi.org/10.1523/JNEUROSCI.4990-13.2014 |
| Language: | English |
| Additional information: | © The Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | calcium, calmodulin, channel, hair cell, inactivation, ribbon synapse |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10164913 |
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