Zhang, Wanchang;
Wang, Hongru;
Brandt, Débora YC;
Hu, Beijuan;
Sheng, Junqing;
Wang, Mengnan;
Luo, Haijiang;
... Hong, Yijiang; + view all
(2022)
The genetic architecture of phenotypic diversity in the Betta fish (Betta splendens).
Science Advances
, 8
(38)
, Article eabm4955. 10.1126/sciadv.abm4955.
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Abstract
The Betta fish displays a remarkable variety of phenotypes selected during domestication. However, the genetic basis underlying these traits remains largely unexplored. Here, we report a high-quality genome assembly and resequencing of 727 individuals representing diverse morphotypes of the Betta fish. We show that current breeds have a complex domestication history with extensive introgression with wild species. Using a genome-wide association study, we identify the genetic basis of multiple traits, including coloration patterns, the "Dumbo" phenotype with pectoral fin outgrowth, extraordinary enlargement of body size that we map to a major locus on chromosome 8, the sex determination locus that we map to dmrt1, and the long-fin phenotype that maps to the locus containing kcnj15. We also identify a polygenic signal related to aggression, involving multiple neural system-related genes such as esyt2, apbb2, and pank2. Our study provides a resource for developing the Betta fish as a genetic model for morphological and behavioral research in vertebrates.
| Type: | Article |
|---|---|
| Title: | The genetic architecture of phenotypic diversity in the Betta fish (Betta splendens) |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1126/sciadv.abm4955 |
| Publisher version: | https://doi.org/10.1126/sciadv.abm4955 |
| Language: | English |
| Additional information: | Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S.Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). |
| Keywords: | Aggression, Animals, Fishes, Genome-Wide Association Study, Phenotype, Sequence Analysis, DNA |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10164886 |
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