Ferrazzoli, V;
Shankar, A;
Cockle, JV;
Tang, C;
Al-Khayfawee, A;
Bomanji, J;
Fraioli, F;
(2023)
Mapping glioma heterogeneity using multiparametric 18F-choline PET/MRI in childhood and teenage-young adults.
Nuclear Medicine Communications
, 44
(1)
pp. 91-99.
10.1097/MNM.0000000000001636.
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Abstract
Objective The heterogeneity of post-treatment imaging remains a significant challenge in children and teenagers/young adults (TYA) diagnosed with glioma. The aim of this study was to evaluate the utility of 18F-choline PET/MRI in determining intratumoural heterogeneity in paediatric and TYA gliomas. Methods Twenty-six patients (mean age 16 years, range 8-22 years) with suspected glioma disease progression were evaluated with 18F-choline PET/MRI. Relative cerebral blood volume (rCBV), apparent diffusion coefficient (ADC) and maximum standardised uptake values (SUVmax) in enhancing (enh) and non-enhancing (ne) tumour volumes and normal-appearing white matter (wm) were calculated (rCBVenh, rCBVne, rCBVwm, ADCenh, ADCne, ADCwm, SUVenh, SUVneand SUVwm). Results Significantly higher SUVenhand SUVnecompared with SUVwmwere observed [SUVenh0.89 (0.23-1.90), SUVne0.36 (0.16-0.78) versus SUVwm0.15 (0.04-1.19); P < 0.001 and P = 0.004, respectively]. Equivalent results were observed for ADV and rCBV (ADCenh, ADCne: P < 0.001 versus ADCwm; rCBVenh, rCBVne: P < 0.001 versus rCBVwm). The highest values for mean SUVmax[0.89 (0.23-1.90)] and mean rCBV [2.1 (0.74-5.08)] were in the enhancing component, while the highest values for ADC [1780 mm2/s (863-2811)] were in the necrotic component. Conclusion 18F-choline PET/MRI is able map imaging heterogeneity in paediatric and TYA gliomas, detecting post-treatment enhancing, non-enhancing, and necrotic tumour components equivalent to ADC and DSC-derived rCBV. This offers potential in the response assessment of diffuse non-enhancing gliomas and in selected cases such as posterior fossa tumours where quantitative MRI is technically difficult.
| Type: | Article |
|---|---|
| Title: | Mapping glioma heterogeneity using multiparametric 18F-choline PET/MRI in childhood and teenage-young adults |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1097/MNM.0000000000001636 |
| Publisher version: | https://doi.org/10.1097/MNM.0000000000001636 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Radiology, Nuclear Medicine & Medical Imaging, F-18-choline PET, glioma, MRI, NERVOUS-SYSTEM TUMORS, BRAIN-TUMORS, F-18-LABELED FLUOROMETHYLCHOLINE, RESPONSE ASSESSMENT, PET, PREDICTION, DIFFUSION, PERFUSION, RECURRENCE |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10164690 |
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