Wan, ER;
Iancu, D;
Ashton, E;
Siew, K;
Mohidin, B;
Sung, CC;
Nagano, C;
... Walsh, SB; + view all
(2022)
Machine Learning to Identify Genetic Salt-Losing Tubulopathies in Hypokalemic Patients.
Kidney International Reports
10.1016/j.ekir.2022.12.008.
(In press).
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Iancu_Machine Learning to Identify Genetic Salt-Losing Tubulopathies in Hypokalemic Patients_AOP.pdf - Published Version Download (1MB) | Preview |
Abstract
Introduction: Clinically distinguishing patients with the inherited salt-losing tubulopathies (SLTs), Gitelman or Bartter syndrome (GS or BS) from other causes of hypokalemia (LK) patients is difficult, and genotyping is costly. We decided to identify clinical characteristics that differentiate SLTs from LK. Methods: A total of 66 hypokalemic patients with possible SLTs were recruited to a prospective observational cohort study at the University College London Renal Tubular Clinic, London. All patients were genotyped for pathogenic variants in genes which cause SLTs; 39 patients had pathogenic variants in genes causing SLTs. We obtained similar data sets from cohorts in Taipei and Kobe, as follows: the combined data set comprised 419 patients; 291 had genetically confirmed SLT. London and Taipei data sets were combined to train machine learning (ML) algorithms, which were then tested on the Kobe data set. Results: Single biochemical variables (e.g., plasma renin) were significantly, but inconsistently, different between SLTs and LK in all cohorts. A decision table algorithm using serum bicarbonate and urinary sodium excretion (FENa) achieved a classification accuracy of 74%. This was superior to all the single biochemical variables identified previously. Conclusion: ML algorithms can differentiate true SLT in the context of a specialist clinic with some accuracy. However, based on routine biochemistry, the accuracy is insufficient to make genotyping redundant.
| Type: | Article |
|---|---|
| Title: | Machine Learning to Identify Genetic Salt-Losing Tubulopathies in Hypokalemic Patients |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ekir.2022.12.008 |
| Publisher version: | https://doi.org/10.1016/j.ekir.2022.12.008 |
| Language: | English |
| Additional information: | ©2022 International Society of Nephrology. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | diagnosis, genotyping, machine learning, tubulopathy |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Renal Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10163646 |
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