Solé-Padullés, C;
Cattaneo, G;
Marchant, NL;
Cabello-Toscano, M;
Mulet-Pons, L;
Solana, J;
Bargalló, N;
... Bartrés-Faz, D; + view all
(2022)
Associations between repetitive negative thinking and resting-state network segregation among healthy middle-aged adults.
Frontiers in Aging Neuroscience
, 14
, Article 1062887. 10.3389/fnagi.2022.1062887.
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Abstract
Background: Repetitive Negative Thinking (RNT) includes negative thoughts about the future and past, and is a risk factor for depression and anxiety. Prefrontal and anterior cingulate cortices have been linked to RNT but several regions within large-scale networks are also involved, the efficiency of which depends on their ability to remain segregated. Methods: Associations between RNT and system segregation (SyS) of the Anterior Salience Network (ASN), Default Mode Network (DMN) and Executive Control Network (ECN) were explored in healthy middle-aged adults (N = 341), after undergoing resting-state functional magnetic resonance imaging. Regression analyses were conducted with RNT as outcome variable. Explanatory variables were: SyS, depression, emotional stability, cognitive complaints, age and sex. Results: Analyses indicated that RNT was associated with depression, emotional stability, cognitive complaints, age and segregation of the left ECN (LECN) and ASN. Further, the ventral DMN (vDMN) presented higher connectivity with the ASN and decreased connectivity with the LECN, as a function of RNT. Conclusion: Higher levels of perseverative thinking were related to increased segregation of the LECN and decreased segregation of the ASN. The dissociative connectivity of these networks with the vDMN may partially account for poorer cognitive control and increased self-referential processes characteristic of RNT.
| Type: | Article |
|---|---|
| Title: | Associations between repetitive negative thinking and resting-state network segregation among healthy middle-aged adults |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fnagi.2022.1062887 |
| Publisher version: | https://doi.org/10.3389/fnagi.2022.1062887 |
| Language: | English |
| Additional information: | Copyright © 2022 Solé-Padullés, Cattaneo, Marchant, Cabello-Toscano, Mulet-Pons, Solana, Bargalló, Tormos, Pascual-Leone and Bartrés-Faz. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | anxiety, depression, repetitive negative thinking, resting-state networks, rumination, system segregation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry > Mental Health of Older People |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10163487 |
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