Pollard, TD;
Seoane-Viaño, I;
Ong, JJ;
Januskaite, P;
Awwad, S;
Orlu, M;
Bande, MF;
... Goyanes, A; + view all
(2023)
Inkjet drug printing onto contact lenses: Deposition optimisation and non-invasive dose verification.
International Journal of Pharmaceutics: X
, 5
, Article 100150. 10.1016/j.ijpx.2022.100150.
(In press).
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Abstract
Inkjet printing has the potential to advance the treatment of eye diseases by printing drugs on demand onto contact lenses for localised delivery and personalised dosing, while near-infrared (NIR) spectroscopy can further be used as a quality control method for quantifying the drug but has yet to be demonstrated with contact lenses. In this study, a glaucoma therapy drug, timolol maleate, was successfully printed onto contact lenses using a modified commercial inkjet printer. The drug-loaded ink prepared for the printer was designed to match the properties of commercial ink, whilst having maximal drug loading and avoiding ocular inflammation. This setup demonstrated personalised drug dosing by printing multiple passes. Light transmittance was found to be unaffected by drug loading on the contact lens. A novel dissolution model was built, and in vitro dissolution studies showed drug release over at least 3 h, significantly longer than eye drops. NIR was used as an external validation method to accurately quantify the drug dose. Overall, the combination of inkjet printing and NIR represent a novel method for point-of-care personalisation and quantification of drug-loaded contact lenses.
| Type: | Article |
|---|---|
| Title: | Inkjet drug printing onto contact lenses: Deposition optimisation and non-invasive dose verification |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ijpx.2022.100150 |
| Publisher version: | https://doi.org/10.1016/j.ijpx.2022.100150 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Point-of-care dispensing, 2D printing, Personalized healthcare, Printing medicines, Process analytical technology (PAT) tools, Ophthalmic and ocular drug delivery |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10162799 |
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