McCoubrey, Laura E;
Favaron, Alessia;
Awad, Atheer;
Orlu, Mine;
Gaisford, Simon;
Basit, Abdul W;
(2023)
Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics.
Journal of Controlled Release
, 353
pp. 1107-1126.
10.1016/j.jconrel.2022.12.029.
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Abstract
Colonic drug delivery can facilitate access to unique therapeutic targets and has the potential to enhance drug bioavailability whilst reducing off-target effects. Delivering drugs to the colon requires considered formulation development, as both oral and rectal dosage forms can encounter challenges if the colon's distinct physiological environment is not appreciated. As the therapeutic opportunities surrounding colonic drug delivery multiply, the success of novel pharmaceuticals lies in their design. This review provides a modern insight into the key parameters determining the effective design and development of colon-targeted medicines. Influential physiological features governing the release, dissolution, stability, and absorption of drugs in the colon are first discussed, followed by an overview of the most reliable colon-targeted formulation strategies. Finally, the most appropriate in vitro, in vivo, and in silico preclinical investigations are presented, with the goal of inspiring strategic development of new colon-targeted therapeutics.
| Type: | Article |
|---|---|
| Title: | Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics |
| Location: | Netherlands |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jconrel.2022.12.029 |
| Publisher version: | https://doi.org/10.1016/j.jconrel.2022.12.029 |
| Language: | English |
| Additional information: | © 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Artificial intelligence and machine learning, Drug delivery systems and the large intestine, Gastrointestinal microbiota and microbiome, Inflammatory bowel disease and drug products, Oral biologics and biopharmaceuticals, Targeting the colon |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10162490 |
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