Rudnicki, Martina;
Pislaru, Alexandra;
Rezvan, Omid;
Rullman, Eric;
Fawzy, Aly;
Nwadozi, Emmanuel;
Roudier, Emilie;
... Haas, Tara L; + view all
(2023)
Transcriptomic profiling reveals sex-specific molecular signatures of adipose endothelial cells under obesogenic conditions.
iScience
, 26
(1)
, Article 105811. 10.1016/j.isci.2022.105811.
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Abstract
Female mice display greater adipose angiogenesis and maintain healthier adipose tissue than do males upon high-fat diet feeding. Through transcriptome analysis of endothelial cells (EC) from the white adipose tissue of male and female mice high-fat-fed for 7 weeks, we found that adipose EC exhibited pronouncedly sex-distinct transcriptomes. Genes upregulated in female adipose EC were associated with proliferation, oxidative phosphorylation, and chromatin remodeling contrasting the dominant enrichment for genes related to inflammation and a senescence-associated secretory of male EC. Similar sex-biased phenotypes of adipose EC were detectable in a dataset of aged EC. The highly proliferative phenotype of female EC was observed also in culture conditions. In turn, male EC displayed greater inflammatory potential than female EC in culture, based on basal and tumor necrosis factor alpha-stimulated patterns of gene expression. Our study provides insights into molecular programs that distinguish male and female EC responses to pathophysiological conditions.
| Type: | Article |
|---|---|
| Title: | Transcriptomic profiling reveals sex-specific molecular signatures of adipose endothelial cells under obesogenic conditions |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.isci.2022.105811 |
| Publisher version: | https://doi.org/10.1016/j.isci.2022.105811 |
| Language: | English |
| Additional information: | © 2022 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10162489 |
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