Shen, Yutong;
Liu, Chengkun;
He, Haijun;
Zhang, Mengdi;
Wang, Hao;
Ji, Keyu;
Wei, Liang;
... Zhou, Fenglei; + view all
(2022)
Recent Advances in Wearable Biosensors for Non-Invasive Detection of Human Lactate.
Biosensors
, 12
(12)
, Article 1164. 10.3390/bios12121164.
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Abstract
Lactate, a crucial product of the anaerobic metabolism of carbohydrates in the human body, is of enormous significance in the diagnosis and treatment of diseases and scientific exercise management. The level of lactate in the bio-fluid is a crucial health indicator because it is related to diseases, such as hypoxia, metabolic disorders, renal failure, heart failure, and respiratory failure. For critically ill patients and those who need to regularly control lactate levels, it is vital to develop a non-invasive wearable sensor to detect lactate levels in matrices other than blood. Due to its high sensitivity, high selectivity, low detection limit, simplicity of use, and ability to identify target molecules in the presence of interfering chemicals, biosensing is a potential analytical approach for lactate detection that has received increasing attention. Various types of wearable lactate biosensors are reviewed in this paper, along with their preparation, key properties, and commonly used flexible substrate materials including polydimethylsiloxane (PDMS), polyethylene terephthalate (PET), paper, and textiles. Key performance indicators, including sensitivity, linear detection range, and detection limit, are also compared. The challenges for future development are also summarized, along with some recommendations for the future development of lactate biosensors.
| Type: | Article |
|---|---|
| Title: | Recent Advances in Wearable Biosensors for Non-Invasive Detection of Human Lactate |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/bios12121164 |
| Publisher version: | https://doi.org/10.3390/bios12121164 |
| Language: | English |
| Additional information: | Copyright © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| Keywords: | lactate detection; non-invasive; wearable biosensors; flexible substrates |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10162101 |
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Loading...Loading...| 1. |  United States | 19 |
| 2. |  United Kingdom | 9 |
| 3. |  China | 5 |
| 4. |  Russian Federation | 5 |
| 5. |  India | 4 |
| 6. |  Vietnam | 3 |
| 7. |  Nepal | 3 |
| 8. |  Norway | 2 |
| 9. |  Iran, Islamic Republic of | 1 |
| 10. |  Portugal | 1 |
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