Ripamonti, Enrico;
Edén, Arvid;
Nilsson, Staffan;
Sönnerborg, Anders;
Zetterberg, Henrik;
Gisslén, Magnus;
(2023)
Longitudinal decline of plasma neurofilament light levels after antiretroviral initiation in people living with HIV.
Journal of Internal Medicine
, 293
(4)
pp. 445-456.
10.1111/joim.13594.
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Journal of Internal Medicine - 2022 - Ripamonti - Longitudinal decline of plasma neurofilament light levels after.pdf - Accepted Version Download (1MB) | Preview |
Abstract
OBJECTIVES: This retrospective follow-up study aims to investigate the dynamic longitudinal change of plasma neurofilament light (NfL) levels after antiretroviral (ART) initiation in a cohort of people living with HIV (PWH). METHODS: We tested a convenience sample of 116 patients from the NORTHIV study. Plasma NfL levels-measured using Single molecule array (Simoa) technology-as well as other laboratory parameters, were collected at baseline, week 4, week 48, week 96, and week 144. Linear mixed-effects models were estimated to evaluate longitudinal change over time. Baseline CD4+ T-cell levels, CDC classification, and HIV RNA levels were considered. Models were adjusted by age, sex, treatment regimen, and baseline serum creatinine levels. RESULTS: Plasma NfL levels were higher at baseline, and also declined faster during the follow-up for participants with CD4+ count <100 cells/μl compared with >100 cells/μl. No significant difference was found between the CD4+ strata 100-199/μl versus 200-499/μl. Participants with CDC classification stages B and C had higher levels of plasma NfL at baseline, as well as faster decline compared with participants with stage A. No significant main effects or change over time were found in baseline HIV RNA levels, treatment regimen, or sex. CONCLUSION: Plasma NfL is a sensitive biomarker to assess ongoing CNS injury in PWH. Plasma NfL concentrations decline relatively fast following ART initiation, and then stabilize after 48 weeks. Plasma NfL concentrations are associated with CD4+ count and stage of HIV disease. No correlations were seen with different ART regimens. This article is protected by copyright. All rights reserved.
| Type: | Article |
|---|---|
| Title: | Longitudinal decline of plasma neurofilament light levels after antiretroviral initiation in people living with HIV |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/joim.13594 |
| Publisher version: | https://doi.org/10.1111/joim.13594 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | ART, CD4+, cerebrospinal fluid NfL, HIV, neuronal injury, plasma NfL |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10161398 |
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