Darne, Chinmay D;
Robertson, Daniel G;
Alsanea, Fahed;
Collins-Fekete, Charles-Antoine;
Beddar, Sam;
(2022)
A novel proton-integrating radiography system design using a monolithic scintillator detector: Experimental studies.
Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
, 1027
, Article 166077. 10.1016/j.nima.2021.166077.
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Abstract
Research on proton-based imaging systems aims to improve treatment planning, internal anatomy visualization, and patient alignment for proton radiotherapy. The purpose of this study was to demonstrate a new proton radiography system design consisting of a monolithic plastic scintillator volume and two optical cameras for use with scanning proton pencil beams. Unlike the thin scintillating plates currently used for proton radiography, the plastic scintillator volume (20 × 20 20 cm^{3}) captures a wider distribution of proton beam energy depositions and avoids proton-beam modulation. The proton imaging system’s characteristics were tested using image uniformity (2.6% over a 5 × 5 cm^{2} area), stability (0.37%), and linearity (R^{2} = 1) studies. We used the light distribution produced within the plastic scintillator to generate proton radiographs via two different approaches: (a) integrating light by using a camera placed along the beam axis, and (b) capturing changes to the proton Bragg peak positions with a camera placed perpendicularly to the beam axis. The latter method was used to plot and evaluate relative shifts in percentage depth light (PDL) profiles of proton beams with and without a phantom in the beam path. A curvelet minimization algorithm used differences in PDL profiles to reconstruct and refine the phantom water-equivalent thickness (WET) map. Gammex phantoms were used to compare the proton radiographs generated by these two methods. The relative accuracies in calculating WET of the phantoms using the calibration-based beam-integration (and the PDL) methods were -0.18 ± 0.35% (-0.29 ± 3.11%), -0.11 ± 0.51% (-0.15 ± 2.64%), -2.94 ± 1.20% (-0.75 ± 6.11%), and -1.65 ± 0.35% (0.36 ± 3.93%) for solid water, adipose, cortical bone, and PMMA, respectively. Further exploration of this unique multicamera-based imaging system is warranted and could lead to clinical applications that improve treatment planning and patient alignment for proton radiotherapy.
| Type: | Article |
|---|---|
| Title: | A novel proton-integrating radiography system design using a monolithic scintillator detector: Experimental studies |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.nima.2021.166077 |
| Publisher version: | https://doi.org/10.1016/j.nima.2021.166077 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| Keywords: | Proton radiography, Plastic scintillator, Proton therapy, CCD camera |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10160590 |
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