Kowalka, Anna M;
Alexiadou, Kleopatra;
Cuenco, Joyceline;
Clarke, Rosemary E;
Minnion, James;
Williams, Emma L;
Bech, Paul;
... Tan, Tricia M-M; + view all
(2022)
The postprandial secretion of peptide YY1-36 and 3-36 in obesity is differentially increased after gastric bypass versus sleeve gastrectomy.
Clinical Endocrinology
10.1111/cen.14846.
(In press).
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Abstract
OBJECTIVES: Peptide tyrosine tyrosine (PYY) exists as two species, PYY1-36 and PYY3-36, with distinct effects on insulin secretion and appetite regulation. The detailed effects of bariatric surgery on PYY1-36 and PYY3-36 secretion are not known as previous studies have used non-specific immunoassays to measure total PYY. Our objective was to characterise the effect of sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) on fasting and post-prandial PYY1-36 and PYY3-36 secretion using a newly developed liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay. DESIGN AND SUBJECTS: Observational study in 10 healthy non-obese volunteers and 30 participants with obesity who underwent RYGB (n=24) or SG (n=6) at the Imperial Weight Centre [NCT01945840]. Participants were studied using a standardised mixed meal test (MMT) before and 1 year after surgery. The outcome measure was PYY1-36 and PYY3-36 concentration. RESULTS: Pre-surgery, the fasting and post-prandial levels of PYY1-36 and PYY3-36 were low, with minimal responses to the MMT, and these did not differ from healthy non-obese volunteers. The postprandial secretion of both PYY1-36 and PYY3-36 at 1 year was amplified after RYGB, but not SG, with the response being significantly higher in RYGB compared to SG. CONCLUSIONS: There appears to be no difference in PYY secretion between non-obese and obese volunteers at baseline. At 1 year after surgery, RYGB, but not SG, is associated with increased post-prandial secretion of PYY1-36 and PYY3-36, which may account for long-term differences in efficacy and adverse effects between the two types of surgery.
| Type: | Article |
|---|---|
| Title: | The postprandial secretion of peptide YY1-36 and 3-36 in obesity is differentially increased after gastric bypass versus sleeve gastrectomy |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/cen.14846 |
| Publisher version: | https://doi.org/10.1111/cen.14846 |
| Language: | English |
| Additional information: | Copyright © 2022 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | LC-MS/MS, PYY, gastric bypass, obesity, type 2 diabetes |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Renal Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10159692 |
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