Pearce, Lucie;
Carr, Richard D;
Yellon, Derek M;
Davidson, Sean M;
(2023)
Nicorandil — an Effective Multitarget Drug for Cardioprotection?
Cardiovascular Drugs and Therapy
, 37
pp. 5-8.
10.1007/s10557-022-07397-x.
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Abstract
Although nicorandil has been in clinical use as a treatment for angina since the 1980s, it remains a fascinating drug with potential actions in cardiac ischaemia. Unusually, it has dual properties as both a nitric oxide (NO) donor and KATP channel opener, by which it can cause coronary artery vasodilation, as well as cardioprotection against ischaemia and reperfusion (I/R) injury. As such, it may be an attractive “multitarget” drug for cardioprotection [1]. A recently published article in Cardiovascular Drugs and Therapy presents evidence that nicorandil may suppress ischaemia-induced ventricular arrhythmias (VA) [2]. In this commentary, we discuss this article in the context of the recent CHANGE clinical trial which saw multiple benefits of nicorandil in the setting of ST-elevation myocardial infarction (STEMI) [3].
| Type: | Article |
|---|---|
| Title: | Nicorandil — an Effective Multitarget Drug for Cardioprotection? |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s10557-022-07397-x |
| Publisher version: | https://doi.org/10.1007/s10557-022-07397-x |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10159106 |
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