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Avoiding interpretational pitfalls in fluorescence imaging of the brain

Rusakov, Dmitri A; (2022) Avoiding interpretational pitfalls in fluorescence imaging of the brain. Nature Reviews Neuroscience , 23 pp. 705-706. 10.1038/s41583-022-00643-z. Green open access

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Abstract

Fluorescent sensors of molecular activity have revolutionized our knowledge of the brain. However, their signals report a reaction between the target and the sensor molecules rather than the activity of interest per se. Thus, understanding the location, sensitivity and imaging environment of a sensor should help to avoid misinterpretation of its readout.

Type: Article
Title: Avoiding interpretational pitfalls in fluorescence imaging of the brain
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41583-022-00643-z
Publisher version: https://doi.org/10.1038/s41583-022-00643-z
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Cellular neuroscience, Neural circuits
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
URI: https://discovery.ucl.ac.uk/id/eprint/10158180
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