Fratzl, A;
Hofer, SB;
(2022)
The caudal prethalamus: Inhibitory switchboard for behavioral control?
Neuron
, 110
(17)
pp. 2728-2742.
10.1016/j.neuron.2022.07.018.
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Abstract
Prethalamic nuclei in the mammalian brain include the zona incerta, the ventral lateral geniculate nucleus, and the intergeniculate leaflet, which provide long-range inhibition to many targets in the midbrain, hindbrain, and thalamus. These nuclei in the caudal prethalamus can integrate sensory and non-sensory information, and together they exert powerful inhibitory control over a wide range of brain functions and behaviors that encompass most aspects of the behavioral repertoire of mammals, including sleep, circadian rhythms, feeding, drinking, predator avoidance, and exploration. In this perspective, we highlight the evidence for this wide-ranging control and lay out the hypothesis that one role of caudal prethalamic nuclei may be that of a behavioral switchboard that—depending on the sensory input, the behavioral context, and the state of the animal—can promote a behavioral strategy and suppress alternative, competing behaviors by modulating inhibitory drive onto diverse target areas.
| Type: | Article |
|---|---|
| Title: | The caudal prethalamus: Inhibitory switchboard for behavioral control? |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.neuron.2022.07.018 |
| Publisher version: | https://doi.org/10.1016/j.neuron.2022.07.018 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, VENTRAL LATERAL GENICULATE, ZONA INCERTA LESIONS, RECEPTIVE-FIELD PROPERTIES, SUPERIOR COLLICULUS, VISUAL-CORTEX, INTERGENICULATE LEAFLET, BASAL GANGLIA, DOPAMINERGIC-NEURONS, HYPOTHALAMIC TRACT, BRAIN-STEM |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10157998 |
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