Peterson, Jessica A;
Strath, Larissa J;
Nodarse, Chavier Laffitte;
Rani, Asha;
Huo, Zhiguang;
Meng, Lingsong;
Yoder, Sean;
... Cruz-Almeida, Yenisel; + view all
(2022)
Epigenetic Aging Mediates the Association between Pain Impact and Brain Aging in Middle to Older Age Individuals with Knee Pain.
Epigenetics
10.1080/15592294.2022.2111752.
(In press).
Preview |
Text
Cole_Peterson et al. Epigenetics author accepted version.pdf - Accepted Version Download (344kB) | Preview |
Abstract
Chronic musculoskeletal pain is a health burden that may accelerate the aging process. Accelerated brain aging and epigenetic aging have separately been observed in those with chronic pain. However, it is unknown whether these biological markers of aging are associated with each other in those with chronic pain. We aimed to explore the association of epigenetic aging and brain aging in middle-to-older age individuals with varying degrees of knee pain. Participants (57.91 ± 8.04 years) with low impact knee pain (n=95), high impact knee pain (n=53) and pain-free controls (n=26) completed self-reported pain, a blood draw and an MRI scan. We used an epigenetic clock previously associated with knee pain (DNAmGrimAge), the subsequent difference of predicted epigenetic and brain age from chronological age (DNAmGrimAge-Difference and Brain-PAD, respectively). There was a significant main effect for pain impact group (F (2,167) = 3.847, p = 0.023, ηp2 = 0.038, ANCOVA) on Brain-PAD and DNAmGrimAge-difference (F (2,167) = 6.800, p = 0.001, ηp2 = 0.075, ANCOVA) after controlling for covariates. DNAmGrimAge-Difference and Brain-PAD were modestly correlated (r=0.198; p=0.010). Exploratory analysis revealed that DNAmGrimAge-difference mediated GCPS pain impact, GCPS pain severity and pain related disability scores on Brain-PAD. Based upon the current study findings, we suggest that pain could be a driver for accelerated brain aging via epigenome interactions.
| Type: | Article |
|---|---|
| Title: | Epigenetic Aging Mediates the Association between Pain Impact and Brain Aging in Middle to Older Age Individuals with Knee Pain |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1080/15592294.2022.2111752 |
| Publisher version: | https://doi.org/10.1080/15592294.2022.2111752 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Aging, brain aging, chronic pain, epigenetics, musculoskeletal pain |
| UCL classification: | UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science UCL > Provost and Vice Provost Offices > UCL BEAMS UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10157158 |
Archive Staff Only
 |
View Item |
