Taylor, Lara;
(2022)
Examining psychobiological mechanisms underlying bipolar spectrum disorder symptom presentation.
Doctoral thesis (D.Clin.Psy), UCL (University College London).
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Abstract
This thesis examines the psychobiological mechanisms underlying bipolar spectrum disorder mood symptom presentation in two parts: dysregulation in short-term affective processes (Part one), and dysregulation in reward processing (Part two). Part one presents a systematic review, which sought to identify convergence of findings from studies using ecological momentary assessment/experience sampling (EMA/ESM) methodology to examine affect dynamics in bipolar spectrum disorder, unipolar depression and borderline personality disorder populations. 38 studies using EMA/ESM methodology to examine affect dynamics across clinical groups and healthy controls were included. Findings showed that altered affect dynamics were identified across all disorders in comparison to healthy controls. Findings suggest that the degree of affect dysregulation may differentiate clinical groups. Part two presents an empirical study, which sought to examine the relationship between reward processing and subthreshold BSD symptoms longitudinally in a large community-based sample, using a monetary incentive delay functional magnetic resonance paradigm. Region-of-interest analyses in the ventral striatum were conducted to examine how neural activation during anticipation of rewards at 14 was related to mood symptoms at 14 and 22 years. Although no association was observed between neural activation and mood symptoms at baseline, enhanced sensitivity to anticipation of rewards, reflected in higher levels of neural activation, at age 14 predicted lower levels of (hypo)manic symptoms at age 22. Part three comprises a critical appraisal of the research process. This includes reflections on the author’s positionality and influences on the research, the challenges of neuroimaging research, and the value of understanding the neurobiological mechanisms underlying psychopathology.
| Type: | Thesis (Doctoral) |
|---|---|
| Qualification: | D.Clin.Psy |
| Title: | Examining psychobiological mechanisms underlying bipolar spectrum disorder symptom presentation |
| Open access status: | An open access version is available from UCL Discovery |
| Language: | English |
| Additional information: | Copyright © The Author 2022. Original content in this thesis is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) Licence (https://creativecommons.org/licenses/by-nc/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author’s request. |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10156931 |
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