Poole, Josephine; Zagaglia, Sara; Demurtas, Rita; Farrell, Fiona; Walker, Matthew C; Sisodiya, Sanjay M; Balestrini, Simona; Poole, Josephine; Zagaglia, Sara; Demurtas, Rita; Farrell, Fiona; Walker, Matthew C; Sisodiya, Sanjay M; Balestrini, Simona; Vivekananda, Umesh; - view fewer (2022) Alternating hemiplegia of childhood: An electroclinical study of sleep and hemiplegia. PLoS One , 17 (9) , Article e0268720. 10.1371/journal.pone.0268720.

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Abstract

OBJECTIVE: Alternating Hemiplegia of Childhood (AHC) is characterised by paroxysmal hemiplegic episodes and seizures. Remission of hemiplegia upon sleep is a clinical diagnostic feature of AHC. We investigated whether: 1) Hemiplegic events are associated with spectral EEG changes 2) Sleep in AHC is associated with clinical or EEG spectral features that may explain its restorative effect. METHODS: We retrospectively performed EEG spectral analysis in five adults with AHC and twelve age-/gender-matched epilepsy controls. Five-minute epochs of hemiplegic episodes and ten-minute epochs of four sleep stages were selected from video-EEGs. Arousals were counted per hour of sleep. RESULTS: We found 1) hemispheric differences in pre-ictal and ictal spectral power (p = 0.034), during AHC hemiplegic episodes 2) 22% reduced beta power (p = 0.017) and 26% increased delta power (p = 0.025) during wakefulness in AHC versus controls. There were 98% more arousals in the AHC group versus controls (p = 0.0003). CONCLUSIONS: There are hemispheric differences in spectral power preceding hemiplegic episodes in adults with AHC, and sleep is disrupted. SIGNIFICANCE: Spectral EEG changes may be a potential predictive tool for AHC hemiplegic episodes. Significantly disrupted sleep is a feature of AHC.

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