Wang, Lei;
Yang, Chuncheng;
Sun, Changning;
Yan, Xiaolong;
He, Jiankang;
Shi, Changquan;
Liu, Chaozong;
... Huang, Lijun; + view all
(2022)
Fused Deposition Modeling PEEK Implants for Personalized Surgical Application: From Clinical Need to Biofabrication.
International Journal of Bioprinting
, 8
(4)
, Article 615. 10.18063/ijb.v8i4.615.
Preview |
Text
615-2265-1-PB.pdf - Published Version Download (8MB) | Preview |
Abstract
Three-dimensional printing (3DP) technology is suitable for manufacturing personalized orthopedic implants for reconstruction surgery. Compared with traditional titanium, polyether-ether-ketone (PEEK) is the ideal material for 3DP orthopedic implants due to its various advantages, including thermoplasticity, thermal stability, high chemical stability, and radiolucency suitable elastic modulus. However, it is challenging to develop a well-designed method and manufacturing technique to meet the clinical needs because it requires elaborate details and interplays with clinical work. Furthermore, establishing surgical standards for new implants requires many clinical cases and an accumulation of surgical experience. Thus, there are few case reports on using 3DP PEEK implants in clinical practice. Herein, we formed a team with a lot of engineers, scientists, and doctors and conducted a series of studies on the 3DP PEEK implants for chest wall reconstruction. First, the thoracic surgeons sort out the specific types of chest wall defects. Then, the engineers designed the shape of the implant and performed finite element analysis for every implant. To meet the clinical needs and mechanical requirements of implants, we developed a new fused deposition modeling technology to make personalized PEEK implants. Overall, the thoracic surgeons have used 114 personalized 3DP PEEK implants to reconstruct the chest wall defect and further established the surgical standards of the implants as part of the Chinese clinical guidelines. The surface modification technique and composite process are developed to overcome the new clinical problems of implant-related complications after surgery. Finally, the major challenges and possible solutions to translating 3DP PEEK implants into a mature and prevalent clinical product are discussed in the paper.
| Type: | Article |
|---|---|
| Title: | Fused Deposition Modeling PEEK Implants for Personalized Surgical Application: From Clinical Need to Biofabrication |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.18063/ijb.v8i4.615 |
| Publisher version: | http://dx.doi.org/10.18063/ijb.v8i4.615 |
| Language: | English |
| Additional information: | © 2022 Author(s). This is an Open-Access article distributed under the term |
| Keywords: | Science & Technology, Technology, Engineering, Biomedical, Materials Science, Biomaterials, Engineering, Materials Science, Three-dimensional printing, Fused deposition modeling, Polyether-ether-ketone, Chest wall reconstruction, CHEST-WALL RESECTION, POLYETHERETHERKETONE PEEK, RECONSTRUCTION, 3D, BONE, BIOMATERIALS, PULMONARY, SURGERY |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10156519 |
Archive Staff Only
 |
View Item |
